Asian Journal of Healthy and Science

The Effect Of Ethanolic Extract Of Katuk Leaf (Sauropus Androgynus) On Malondialdehyde (MDA) Levels In Ovalbumin-Induced Atopic Dermatitis Model Mice

2025-09-17T03:45:40+00:00

Background: Consensus guidelines have been developed to provide current and concise evidence-based recommendations directed to general practitioners and dermatologists in the Asia-Pacific region regarding the management of pediatric and adult AD. In previous studies there were differences regarding MDA levels in AD and non-AD patients. This can be an indication of oral antioxidants to reduce MDA levels in AD patients. Antioxidants themselves are contained in many traditional medicinal plants that are often found in Indonesia, including katuk leaves. Objective: To analyze the effect of the ethanol extract of katuk leaves (Sauropus androgynus) on MDA levels in mice model of atopic dermatitis induced by ovalbumin. Methods: This study used an experimental method using mice with a total sample of 36 individuals. The dosages of katuk leaf extract used were 100 mg/Kg, 200 mg/Kg, and 400 mg/Kg, the parameters measured were plasma MDA and skin tissue using the Wills method. The results obtained will be processed using the One Way ANOVA test and the Kruskal Wallis test. Results: The results of this study were the value of plasma MDA levels in the DA model mice had higher levels than non-DA with a value of 570.5 nmol / L as well as tissue MDA levels with a value of 1727 nmol / g. However, based on the results of different tests between groups with both plasma and tissue MDA variables, both of them had a p value> 0.05, which means they did not have a significant difference between groups. Conclusion: In this study, the results were not significant in giving ethanol extract of katuk leaves on plasma and tissue MDA levels in DA model mice.

The Effect Of Close Contact History And Housing Density On The Incidence Of Tuberculosis In The Lembeyan Health Center Area, Magetan Regency

2025-09-17T03:47:30+00:00

Based on a report from the Magetan Regency Health Office in 2021-2023, tuberculosis (TB) cases increased by 309 cases. In the working area of the Lembeyan Health Center, the number of TB cases increased to 33 cases in 2023–2024. This suggests that TB is still a health problem that needs attention. This study aims to analyze the effect of close contact history and residential density on TB incidence. The type of research used is observational analytics with a case control design. The research sample amounted to 34 respondents consisting of 17 cases and 17 controls, selected using the purposive sampling method. Data was collected through questionnaires and observation sheets. Data analysis was carried out univariately, bivariate with chi-square test. The results showed that there was a significant influence between the history of close contact (p=0.002) and residential density (p=0.016) with the incidence of TB. The conclusion of this study is that there is a significant influence between the history of close contact and residential density with the incidence of TB. Therefore, TB prevention needs to be focused on improving residential environmental conditions, education of at-risk groups, and monitoring of individuals with a history of close contact with TB patients.

Mental Health Issues Among Online Game Addicts at Smpn 2 Dolopo, Dolopo District, Madiun Regency

2025-10-21T13:55:30+00:00

Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by recurrent synovial inflammation, leading to joint damage, functional limitations, and reduced quality of life. High disease activity is often accompanied by psychological problems, particularly anxiety and depression. Objective: This study aims to evaluate the relationship between disease activity levels based on the Disease Activity Score 28–C-reactive protein (DAS28-CRP) and symptoms of anxiety and depression assessed using the Hospital Anxiety and Depression Scale (HADS) in RA patients at Royal Prima Hospital in Medan. Method: The study used an observational analytical design with a cross-sectional approach. A total of 58 RA patients were selected using simple random sampling. Data were collected through DAS28-CRP examinations and HADS questionnaires, then analyzed using Spearman's correlation test. Results: Of the 58 respondents, most were female (91.4%) with the highest disease activity distribution in the high category (41.4%). The majority of respondents showed normal anxiety levels (81.0%) and normal depression (82.8%). Statistical analysis showed a significant correlation between disease activity and anxiety (r = 0.304; p = 0.020), while no significant relationship was found with depression (r = 0.246; p = 0.062). Conclusion: Disease activity in AR affects patients' anxiety levels but is not proven to be associated with depression. These results emphasize the importance of considering psychological aspects in the comprehensive management of AR patients.